Copyright(c) 2023 First Databank, Inc. Consult your doctor before breast-feeding. Either increases effects of the other by pharmacodynamic synergism. Steps on how to print your input & results: 1. Either increases effects of the other by pharmacodynamic synergism. You can further save the PDF or print it. J Med. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Use Caution/Monitor. Use Caution/Monitor. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. Applies only to oral form of both agents. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Jacobs P, Dommisse J. Modify Therapy/Monitor Closely. This website is intended for use by US healthcare professionals only. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Applies only to oral form of both agents. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. iron sucrose increases levels of calcium acetate by enhancing GI absorption. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. We comply with the HONcode standard for trustworthy health information. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Modify Therapy/Monitor Closely. The dosage of Venofer is expressed in mg of elemental iron. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Each mL contains 20 mg of elemental iron. Assure stable intravenous access to avoid extravasation. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Fatal reactions have followed the test dose of iron dextran injection. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. Reactions have occurred following the first dose or subsequent doses of Venofer. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Applies only to oral form of both agents. Kumpf VJ. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. (3) Known hypersensitivity to Venofer. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. May increase risk of hypotension. If we don't have the calculator you need then tell us the details and we'll make it for you. Applies only to oral form of both agents. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Applies only to oral form of both agents. Although the original formula requires the weight in kilograms, values input in lbs are transformed. Anemia; 2015: 763576. elemental iron (mg/ml) in the product being used: Where C= Minor/Significance Unknown. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Am J Hosp Pharm. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. 5. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Venofer has not been studied in patients younger than 2 years old. 1970; 100(7):301-3. vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Observed Hb = the patients current hemoglobin in g/dl. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Use Caution/Monitor. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . Where: Medicine concentration Amount of active substance per a given volume of your drug. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Creating an account is free and takes less than 1 minute. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. ONE DOSE. Each mL contains 20 mg of elemental . Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). The recipient will receive more details and instructions to access this offer. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Applies only to oral form of both agents. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. . Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] 1998 Feb;25(1):65-8. Med J Aust. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Use Caution/Monitor. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Read our. Deferasirox chelates iron. Access your plan list on any device mobile or desktop. 1982;13(4):309-21. 1990 Feb;24(2):162-6. The dosage of iron sucrose is expressed in mg of elemental iron. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Minor/Significance Unknown. Treatment of anemia due to iron deficiency. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. Venofer treatment may be repeated if necessary. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. Official Journal of the International Society of Nephrology. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. This document does not contain all possible drug interactions. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Contraindicated. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Anemia. Avoid or Use Alternate Drug. By using this form you agree with the storage and handling of your data by this website. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Minor/Significance Unknown. Max Dose. Applies only to oral form of both agents. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] iron sucrose, captopril. Where C= concentration of These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Ren Fail. Applies only to oral form of both agents. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. LBW = Lean body weight in kg. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. Test Dose: Not required. Monitor Closely (1)trientine, iron sucrose. Use Caution/Monitor. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Applies only to oral form of both agents. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. This topic . Kumpf VJ, Holland EG. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Applies only to oral form of both agents. Most IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Avoid or Use Alternate Drug. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Applies only to oral form of both agents. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Use alternatives if available. Minor/Significance Unknown. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. Use Caution/Monitor. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Applies only to oral form of both agents. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Separate dosing of tetracyclines from these products. Burns DL, Mascioli EA, Bistrian BR. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. STORAGE: Consult the product instructions and your pharmacist for storage details. Discard unused portion. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Applies only to oral form of both agents. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . 2010;18(3). Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Do not administer Venofer to patients with iron overload. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Applies only to oral form of both agents. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Venofer must only be administered intravenously either by slow injection or by infusion. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Applies only to oral form of both agents. Applies only to oral form of both agents. DICP. J Lab Clin Med. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. 10th ed. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Assessing new treatment options. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Our dosage calculator can help you with this as well. For liquid medications, also enter the value of the Medicine Concentration and choose . 2015: 763576. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Use Caution/Monitor. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Applies only to oral form of both agents. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Applies only to oral form of both agents. This drug is available at a higher level co-pay. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Modify Therapy/Monitor Closely. Schweiz Med Wochenschr; 100(7):301-3. Use Caution/Monitor. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD).
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